Postdoctoral Fellow - Cellular Modelling Project



Postdoctoral Fellow - Cellular Modelling Project


Cambridge, Cambridgeshire, United Kingdom 

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Postdoctoral Fellow - Cellular Modelling Project (Sandhu Faculty)Three years fixed term.Applications are invited for a Postdoctoral Fellow to join the Global Health and Population Group led by Dr Sandhu at WTSI. The group‘s areas of research include large-scale sequencing efforts to characterise genetic diversity across Africa at the genome-wide level (e.g. the African Genome Variation Project1) or with focus on complex regions such us the HLA, global indigenous populations (e.g. aboriginal Australians2), transcriptomics, whole genome association studies of cardiometabolic and infectious disease traits in African populations, cellular genomics in diverse populations, and functional studies on iPSC lines.The post-holder will be required to coordinate a collaborative project examining the genetic determinants of HIV viral control in ethnically diverse populations. In specific, they will coordinate, across different laboratories at the Wellcome Trust Sanger Institute and the University of Cambridge, the tranche of the project investigating the role of a novel candidate locus in HIV integration and replication using cellular models. Currently, we are in the process of generating iPSC knockouts for genes near the candidate variant using CRISPR. These will then be differentiated into relevant cell lines, for gene expression profiling and assessment of replication efficiency of HIV, to identify biological mechanisms potentially underlying the observed association. This study will provide the first proof-of-concept of the utility of such cellular models for the examination of the underlying biology of HIV replication. Identification of a novel biological association with HIV viral control would be an invaluable step towards identification of therapeutic targets, and development of novel treatment for disease. The project will also be the first effort toward setting up a global panel for target drug cellular modelling.The successful candidate will work collaboratively to integrate the contribution of each laboratory involved so that the project proceeds smoothly and according to schedule. This is also an exceptional opportunity for candidates to enhance their knowledge and skills, as training opportunity will be offered (e.g. cellular differentiation), while working at the frontline of cellular modelling research in a group recognised for their research excellence.Gurdasani, D et al. The African Genome Variation Project: A framework for medical genetics in Africa. Nature 517(7534):327-32 (2015) doi: 10.1038/nature13997Malaspinas A-S et al. A genomic history of Aboriginal Australia. Nature (Published online 21 September) (2016) doi: 10.1038/nature18299Essential Skills:- PhD in relevant scientific discipline (cellular/molecular biology)- Practical molecular biology experience from degree and subsequent scientifically relevant work experience- Accomplished at multiple scientific techniques- Methodical and thorough in approach- Able to work independently- Well organised- Adaptable, enthusiastic and approachable- Ability to coordinate projects and supervise work- Ability to work within and across teams and lead technical aspects of a project- IT proficient- Good problem-solving and troubleshooting skills- Excellent communication skills- Ability to keep good scientific records- Comprehension of groups research- Manually dextrousIdeal Skills:- Experience with iPSC derivation- Experience with cellular modellingOther information:The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.Position will be offered at the Postdoctoral Fellow level and will be Fixed-Term for 3 years. Please include a covering letter and CV with your application.Closing date for applications: 18th January 2017; however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline
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Swindon, Wiltshire, United Kingdom

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